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Most artificial cannabinoids are agonists in the cannabinoid receptors. They are actually built to be comparable to THC,[nine] the natural cannabinoid Using the strongest binding affinity to your CB1 receptor, which is associated with the psychoactive results or "significant" of cannabis.[10] These synthetic analogs typically have larger binding affinity and bigger potency to the CB1 receptors.
The rationale for your modify on the quinolone substructure is mysterious, but it may well happen to be found being a suitable replacement for that naphthoyl moiety which is now regulated by US scheduling laws.[83]
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